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灭滴灵具有广谱抗厌氧菌作用。用于厌氧菌感染的治疗获得满意效果而受到医学界广泛重视,有学者称之为灭滴灵时代。有关其用途、药用评价、疗效观察等文献屡有报道,现将其在儿科的临床应用综述如下。一、适应证1.新生儿败血症新生儿败血症是新生儿重要感染性疾病之一,据资料统计,活产新生儿中达1~5%,在早产婴儿及危重病儿中,败血症更多。厌氧菌感染在新生儿败血症中占有一定位置,易被漏诊,值得重视。其治疗选用氯霉素、氯林可霉素及灭滴灵均有较好效果,但氯霉素在新生儿(尤其是早产儿)可致灰婴综合征,一般疑及厌氧菌感染时,宜选用灭滴灵。
Metronidazole broad-spectrum anti-anaerobic effect. For the treatment of anaerobic infections get satisfactory results by the medical community widely attention, some scholars call melanin era. For its use, medicinal evaluation, curative effect observation and other literature has repeatedly reported, now its clinical application in pediatrics are summarized below. Indications 1. Neonatal septicemia Neonatal sepsis is one of the important infectious diseases of the newborn. According to statistics, up to 1% to 5% of live births are newborn, and sepsis is more in premature infants and critically ill children. Anaerobic infections occupy a certain position in neonatal sepsis, easily missed diagnosis, it is worth attention. The treatment of chloramphenicol, clindamycin and metronidazole are better, but chloramphenicol in neonates (especially premature children) can cause gray infant syndrome, the general suspicion and anaerobic infections , Should use metronidazole.