论文部分内容阅读
目的:制备穿心莲内酯复合粒子,并对其粒子结构与溶出度进行评价。方法:采用机械粉碎法制备穿心莲内酯与聚乙二醇(PEG)6000复合粒子;通过扫描电镜(SEM)与差示扫描量热仪(DSC)表征复合粒子的结构;采用接触角测定仪测定其接触角;考察其体外溶出曲线。结果:穿心莲内酯与PEG 6000形成相互包覆的复合粒子结构,且穿心莲内酯结晶度下降。以水为测定液,穿心莲内酯与PEG 6000复合粒子粉体的接触角明显小于其原粉与物理混合物,且复合粒子的体外溶出速率明显优于其原料、超微粉及其物理混合物。结论:基于机械粉碎的穿心莲内酯复合粒子能显著提高穿心莲内酯的体外溶出度。
OBJECTIVE: To prepare andrographolide composite particles and evaluate their particle structure and dissolution. METHODS: The andrographolide and polyethylene glycol (PEG) 6000 composite particles were prepared by mechanical pulverization method. The structure of the composite particles was characterized by scanning electron microscopy (SEM) and differential scanning calorimeter (DSC) Its contact angle; investigate its in vitro dissolution curve. RESULTS: Andrographolide and PEG 6000 formed a composite particle structure and the crystallinity of andrographolide decreased. The contact angle of the andrographolide and PEG 6000 composite particles was significantly less than that of the original powder and the physical mixture, and the in vitro dissolution rate of the composite particles was significantly better than that of the raw material, superfine powder and their physical mixtures. Conclusion: The andrographolide composite particles based on mechanical pulverization can significantly improve the in vitro dissolution of andrographolide.