胆管癌（CC）是一种起源于胆管上皮细胞的恶性肿瘤，且恶性程度高、预后差。目前的治疗方法主要有根治性切除手术、姑息手术、化疗、放疗等，但这些方法对患者的生存影响甚微。125I放射性粒子植入是近年来新兴的一种肿瘤治疗技术，它具有较好的安全性和有效性，与其他技术相结合能有效改善CC患者的生存，但也存在着一些不足。笔者就125I放射性粒子植入治疗CC的进展做一综述。“,”Cholangiocarcinoma (CC) is a malignant tumor originating from the epithelial cells of the bile ducts with high degree of malignancy and poor prognosis. Current treatment methods mainly include radical resection, palliative surgery, chemotherapy, and radiotherapy, but all these methods exert little impact on patients’ survival.125I seed implantation is a recently emerging technique for cancer therapy. It has better safety and effcacy, and can effectively improve the survival of CC patients in combination with other treatment methods, but still has some disadvantages. Here, the authors present the progress of125I seed implantation in CC treatment.