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目的研究乳酸脱氢酶(lactic dehydrogenase,LDH)及胆碱酯酶(cholinesterase,CHE)在急性白血病中变化的临床意义。方法采用全自动生化分析仪测定急性白血病(acute leukemia,AL)患者于初发/复发组、完全缓解组(complete remission,CR)、未缓解组(no remission,NR)血清中乳酸脱氢酶(serum lactic dehydrogenase,sLDH)和胆碱酯酶(serum cholinesterase,sCHE)的水平,与正常对照组进行比较。结果 AL患者的sLDH初发/复发组比正常对照组和CR组活性升高,sCHE降低,差异有统计学意义(P<0.001),而CR组与正常对照组比较差异无统计学意义(P>0.05)。NR组sLDH、sCHE与CR组及正常对照组比较差异有统计学意义(sLDH P<0.05、P<0.001,sCHE P<0.05,P<0.001),初发/复发组与NR组比较差异无统计学意义(P>0.05)。结论在AL的初发/复发时sLDH活性升高、sCHE活性降低,有助于急性白血病诊断及病情变化判断。
Objective To study the clinical significance of the changes of lactic dehydrogenase (LDH) and cholinesterase (CHE) in acute leukemia. Methods The levels of lactate dehydrogenase (LDH) in serum of patients with acute leukemia (AL) were determined by automatic biochemical analyzer in patients with primary leukemia / relapse, complete remission (CR) and no remission (NR) serum lactic dehydrogenase (sLDH) and serum cholinesterase (sCHE) were measured and compared with the normal control group. Results Compared with the normal control group and the CR group, the sLDH in AL patients had higher activity and lower sCHE than those in normal control group and CR group (P <0.001), while there was no significant difference between CR group and normal control group (P > 0.05). There were significant differences between NR group sLDH, sCHE and CR group and normal control group (sLDH P <0.05, P <0.001, sCHE P <0.05, P <0.001) Significance (P> 0.05). Conclusion The sLDH activity and sCHE activity are decreased during the initial AL / relapse, which is helpful for the diagnosis of acute leukemia and the judgment of the changes of the disease.