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目的：寻找新型肿瘤光动力治疗敏化剂。方法：以蚕沙糊状叶绿素为原料，经酸降解、碱氧化反应合成二氢卟吩ｆ（１），并测定其肿瘤光生物活性。结果：１ 的ＵＶ，ＩＲ，１ＨＮＮＲ及ＦＡＢＭＳ数据系首次报道。１ 在重水中对ＮＡＤＰＨ 光氧化作用的敏化效应和对小鼠Ｓ１８０ 肉瘤的光动力疗效均较参比药物血卟啉衍生物（ｈｅｍａｔｏｐｏｒｐｈｙｒｉｎ ｄｅｒｉｖａｔｉｖｅ，ＨＰＤ） 强。结论：提示１ 是一种有发展前途的肿瘤光动力敏化剂，值得深入研究。
Objective: To find a new type of tumor photodynamic therapy sensitizer. Methods: Chlorimuron f (1) was synthesized by the silkworm paste mulberry chlorophyll with acid degradation and alkali oxidation reaction. The photobiological activity of the compound was determined. Results: 1 UV, IR, 1HNNR and FAB MS data was first reported. 1 sensitized effect of NADPH photooxidation and photodynamic therapy to mouse S180 sarcoma in heavy water were better than the reference drug hematoporphyrin derivative (HPD). Conclusion: Tip 1 is a promising tumor photodynamic sensitizer, worth in-depth study.