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目的:比较分析冠脉内注射硝酸甘油与维拉帕米对冠心病经皮冠状动脉介入术(PCI)中慢血流及无复流的影响。方法:以本院2014年2月~2016年2月行PCI术中发生慢血流、无复流患者78例为研究对象,根据不同给药方式将其分为硝酸甘油组与维拉帕米组,比较两组治疗前后冠脉TIMI分级、TIMI帧数、血压变化情况,同时统计两组住院期间、PCI术后30d不良心血管事件发生率。结果:两组治疗后IMI分级较治疗前显著上升,RCA、LAD、校正LAD、LCX帧数则显著下降,差异有统计学意义,维拉帕米组治疗后上述指标均显著优于硝酸甘油组;两组治疗前后血压无显著变化;硝酸甘油组住院期间、术后30d不良心血管事件发生率分别为17.07%、21.95%,均显著高于维拉帕米组的2.70%、5.40%,差异有统计学意义。结论:冠脉内注射硝酸甘油、维拉帕米均能有效改善冠心病PCI术中慢血流、无复流现象,但后者效果更明显,且能明显降低住院期间及术后30d不良心血管事件发生率。
Objective: To compare the effects of intracoronary nitroglycerin and verapamil on slow and no-reflow in patients with coronary artery disease undergoing percutaneous coronary intervention (PCI). Methods: From February 2014 to February 2016, 78 patients with slow blood flow and no-reflow occurred in our hospital from February 2014 to February 2016. The patients were divided into nitroglycerin group and verapamil The TIMI grading, TIMI frames and blood pressure were compared between the two groups before and after treatment. The incidence of adverse cardiovascular events at 30 days after PCI was also calculated. Results: The scores of IMI increased significantly after treatment in both groups, and the numbers of RCA, LAD, corrected LAD and LCX decreased significantly, the difference was statistically significant. The above indexes in verapamil group were significantly better than those in nitroglycerin group ; There was no significant difference in blood pressure between the two groups before and after treatment; during the hospitalization period, the incidences of adverse cardiovascular events at 30 days after operation were 17.07% and 21.95% in the nitroglycerin group, which were significantly higher than those in the verapamil group (2.70% and 5.40%, respectively) There is statistical significance. CONCLUSION: Both intracoronary nitroglycerin and verapamil can effectively improve the slow blood flow and no-reflow phenomenon in patients with coronary artery disease during PCI, but the latter effect is more obvious, and can significantly reduce the rate of adverse cardiac events during hospitalization and 30 days after PCI The incidence of vascular events.