目的探讨谷维素联合马来酸曲美布汀治疗肠激惹综合征的疗效。方法将61例肠激惹综合症患者随机分为两组,治疗组31例用马来酸曲美布汀和谷维素治疗;对照组30例使用氟西汀和谷维素治疗。结果治疗组和对照组的显效率和总有效率分别是64.5%、90.3%和26.7%、53.3%,差异有统计学意义。结论谷维素联合马来酸曲美布汀治疗肠激惹综合症疗效明显。 Objective To investigate the effect of oryzanol and trimebutine maleate in the treatment of irritable bowel syndrome. Methods Sixty-one patients with irritable bowel syndrome were randomly divided into two groups. 31 cases in the treatment group were treated with trimebutine maleate and oryzanol, and 30 cases in the control group were treated with fluoxetine and oryzanol. Results The effective rate and total effective rate of the treatment group and the control group were 64.5%, 90.3% and 26.7%, 53.3% respectively, the difference was statistically significant. Conclusion Oryzanol combined with trimebutine maleate is effective in treating irritable bowel syndrome.