糖尿病与认知功能损害都是中老年人易患疾病。糖尿病是脑卒中的已知危险因素,会导致血管性痴呆,但与阿尔茨海默病之间的相关性仍无定论,大多数研究认为两者呈正相关,部分研究认为两者无关。阿尔茨海默病有明显的脑内胰岛素抵抗现象,胰岛素及其增敏剂类药物不仅能够提高胰岛素受体的敏感度,还能够减轻炎症反应、促进Aβ淀粉样蛋白的释放和清除,有益于记忆功能的改善。 Diabetes and cognitive impairment are susceptible to diseases in the elderly. Diabetes mellitus is a known risk factor for stroke and leads to vascular dementia. However, the correlation between diabetes and Alzheimer’s disease remains inconclusive. Most studies consider the two to be positively correlated, and some studies suggest that they are not related. Alzheimer’s disease has obvious intracerebral insulin resistance phenomenon. Insulin and its sensitizers can not only increase the sensitivity of insulin receptor, but also reduce the inflammatory reaction, promote the release and clearance of Aβ amyloid, Memory improvement.