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目的描述北京地区45～74岁人群高敏C反应蛋白(hs-CRP)水平的分布特点,分析hs-CRP与代谢综合征(MS)及其各组份间的关系。方法于2002—2004年对北京地区45～74岁人群进行心血管病危险因素检查,并加入了hs-CRP指标。对资料完整的1544人进行分析。MS诊断采用NCEP-ATPⅢ修订后的标准。结果(1)北京地区45～74岁人群hs-CRP水平的中位数为1.00 mg/L,几何均数为(0.79±9.59)mg/L。hs-CRP水平随年龄的增长呈增加趋势(P<0.05),男女两性间的差异无统计学意义(P>0.05)。(2)将hs-CRP按四分位进行分层后,随hs-CRP水平的增加,MS患病率也增加且呈线性趋势(P<0.01),在hs-CRP最高四分位组,血压异常所占的比例最高(74.6%),其次为腹部肥胖(71.7%)。单因素分析显示:hs-CRP最高四分位组患MS的危险是最低四分位组的6.77倍。在调整了年龄、性别、吸烟和饮酒后,多因素logistic回归分析显示:以hs-CRP最低四分位组为参照,hs-CRP最高四分位组发生MS各组份异常的危险均增加,其患MS的危险是最低四分位组的6.35倍。结论hs-CRP水平随年龄的增长而增加,且与MS各组份异常密切相关。
Objective To describe the distribution of hs-CRP in 45-74 years old population in Beijing and to analyze the relationship between hs-CRP and metabolic syndrome (MS) and its components. Methods From 2002 to 2004, cardiovascular disease risk factors were examined in 45-74 years-olds in Beijing and hs-CRP indicators were added. Analysis of 1544 people with complete data. MS diagnosis using NCEP-ATPⅢ revised standards. Results (1) The median hs-CRP level in Beijing aged 45-74 years old was 1.00 mg / L, with a geometric mean of (0.79 ± 9.59) mg / L. The hs-CRP level increased with age (P <0.05), but there was no significant difference between men and women (P> 0.05). (2) After the hs-CRP was stratified by quartile, with the increase of hs-CRP, the prevalence of MS also increased and showed a linear trend (P <0.01). In the highest quartile of hs-CRP, Abnormal blood pressure accounted for the highest proportion (74.6%), followed by abdominal obesity (71.7%). Univariate analysis showed that the risk of developing MS in the highest quartile of hs-CRP was 6.77 times that of the lowest quartile. After adjusting for age, sex, smoking and drinking, multivariate logistic regression analysis showed that at the lowest hs-CRP quartile, the risk of MS abnormalities in the highest quartile of hs-CRP increased, The risk of MS is 6.35 times that of the lowest quartile. Conclusion The hs-CRP level increases with age, and is closely related to the abnormalities of MS components.