成功的治疗肠球菌心内膜炎,要求合并使用青霉素加一种氨基甙类抗菌素。因此,作者曾对单独及合并使用青霉素(Pen.)、链霉素(Str.)和乙基西梭霉素(Net.)——一种新的氨基甙类抗菌素在试管内和用于治疗家兔实验性肠球菌心内膜炎的有效性作了研究(译者注:据报导乙基西梭霉素的优点是:对听神经及肾脏的毒性比目前临床应用的氨基甙类为低;对耐庆大霉素的肠道细菌及绿脓杆菌有强的抗菌、杀菌作用;对某些革兰氏阴性菌亦比丁胺卡那霉素强,故国外认为本品有进行临床试验的价值)。试管内试验结果表明,对肠球菌链霉素敏感株(1号菌株)用Pen.+Str.或Net.比单用Pen.、Str.或Net.的杀菌效果更迅速和更完全;对链霉素高度抗药性株(2号菌株)表明以Pen.+Net.优于 Successful treatment of enterococcal endocarditis, requiring the combined use of penicillin plus an aminoglycoside antibiotic. Therefore, the authors used penicillin, streptomycin (Str.) And netilmicin (Net.) Alone and in combination - a new aminoglycoside antibiotic in vitro and for treatment The efficacy of rabbit experimental enterococcal endocarditis has been studied. (Translator’s Note: The reported advantage of ethosmin is that the toxicity to the auditory nerve and kidneys is lower than that of currently available aminoglycosides; Gentamicin-resistant enteric bacteria and Pseudomonas aeruginosa has a strong antibacterial, bactericidal effect; for some Gram-negative bacteria than amikacin strong, so that foreign products that have clinical trials value). In vitro test results showed that the bactericidal effect of penicillin-streptomycin-sensitive strain (strain No. 1) with Pen. + Str. Or Net. Was faster and more complete than with Pen., Str. Or Net. High-resistant strain of strain (strain No. 2) showed Pen. + Net