一次急性大剂量青蒿素(500mg/kg)腹腔注射小鼠后,其血清对正常异体脾细胞经ConA 活化的~ 3H-UR 掺入有抑制作用。8小时的血清青蒿素浓度已降低,并不影响抑制,表明其在体内的代谢产物也参与了抑制作用。本文首次证明了去氧青蒿素对 ConA 活化的脾淋巴细胞的~H-UR 掺入有抑制作用。青蒿素和代谢产物的共同作用,导致了活化的淋巴细胞上述抑制作用。 After an acute and high dose of artemisinin (500 mg / kg) was intraperitoneally injected into mice, its serum inhibited the incorporation of ~ 3H-UR by ConA-activated normal allogeneic splenocytes. Eight hours of serum artemisinin concentration has been reduced, does not affect the inhibition, indicating that its in vivo metabolites are also involved in the inhibition. This article, for the first time, demonstrates that deoxyartemisinin inhibits the ~ H-UR incorporation of ConA-activated spleen lymphocytes. The combined effect of artemisinin and its metabolites has led to the aforementioned inhibitory effects on activated lymphocytes.