血吸虫的感染和免疫动力学方面的许多问题仍未解决,甚至缺乏感染者虫荷的近似数。作者指出,流行区个体虫荷数应是成百上千条,而不是根据现有尸检资料而假定的几条至几十条。作者的这种假设对该病的研究和控制有重要影响,许多血吸虫病研究中的常数须重新加以考虑。没有测定虫荷的方法,将很难评估一种疫苗的保护效果。有效治疗后的低度感染往往不能用粪检的方法检测。 Much of the problems with schistosomiasis infection and immunological kinetics remain unresolved, and there is even a lack of an approximation of the infestation of worms. The authors note that the prevalence of individual insect loads should be hundreds, rather than the few that are assumed based on current autopsy data. The authors’ hypothesis has a major impact on the study and control of the disease, and many of the constants in schistosomiasis studies need to be reconsidered. Without a method of measuring insect load, it will be difficult to assess the protective effect of a vaccine. Low-level infection after effective treatment often can not be detected by the method of fecal examination.