毛细胞白血病是一种少见病,病程长短不等(数天～15年),切脾治疗只1/3病人有效。但血液学检查常在数月或数年后恶化,死亡多由于感染。有些作者认为类固醇、雄性激素或化疗有效。一般说来仅当患者骨髓为白血病细胞所取代而引起严重中性粒细胞和血小板减少并威胁生命时才应用化疗。本文报告了两例用正定踪(rubidazone)治疗取得令人鼓舞的效果。例一为30岁男性,骨髓穿刺有14%疑为毛细胞,经骨髓活检诊断为毛细胞白血病,由于脾大肋下6厘米并有全血细胞减少而切脾。术后血象一度好转,5个月后,骨髓中白血病细胞逐渐增加到74%,由于严重粒细胞和血小板减少,乃开始用正定腙治疗,剂量为450毫克/米~2,第一次用药后13天骨髓活检,白血 Hairy cell leukemia is a rare disease, ranging in duration (days to 15 years), splenectomy treatment only 1/3 of patients effective. However, hematology often deteriorates in months or years, with more deaths due to infection. Some authors believe that steroids, androgens or chemotherapy are effective. Chemotherapy is generally applied only when the patient’s bone marrow is replaced by leukemia cells that cause severe neutropenia and thrombocytopenia and threaten life. This article reports two encouraging results with rubidazone. One example is a 30-year-old man with 14% of bone marrow punctures suspected of hair cells, bone marrow biopsy diagnosed as hairy cell leukemia, due to spleen ribs 6 cm and pancytopenia and spleen. After the blood was once improved, 5 months later, leukemia cells in bone marrow gradually increased to 74%, due to severe granulocytes and thrombocytopenia, is beginning with positive hydrazone treatment, a dose of 450 mg / m ~ 2 after the first dose Thirteen days bone marrow biopsy, white blood