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采用间接免疫荧光法对自身免疫性甲状腺疾病 ( Autoimmune thyroiddisease,AITD)合并远端肾小管性酸中毒 ( Distal renal tubular acidosis,DRTA) 30例及自身免疫性甲状腺疾病不合并远端肾小管性酸中毒 30例患者进行肾小管抗体测定 ,并与健康人比较。结果显示 :合并远端肾小管性酸中毒组有 9例肾小管抗体阳性 ,阳性率为 30 % ,该组甲状腺球蛋白抗体及甲状腺微粒体抗体浓度明显高于不合并远端肾小管性酸中毒组及健康组 ,后两组肾小管抗体均阴性。提示部分肾小管抗体可能来自甲状腺的自身抗体 ,它们具有免疫交叉反应。其抗原可能系肾小管细胞胞浆 ,这种反应损坏肾小管而导致了肾小管性酸中毒。
Indirect immunofluorescence was used to detect the expression of autoimmune thyroid disease (AITD) in 30 patients with distal renal tubular acidosis (DRTA) and autoimmune thyroid disease without distal renal tubular acidosis Thirty patients were assayed for tubule antibody and compared with healthy individuals. The results showed that: the group of patients with distal renal tubular acidosis, 9 cases of tubule antibody positive, the positive rate was 30%, the group of thyroglobulin antibody and thyroid microsomal antibody concentrations were significantly higher than those without distal renal tubular acidosis Group and healthy group, the latter two groups of renal tubular antibodies were negative. Tip part of the tubular antibodies may be from the thyroid autoantibodies, they have immune cross-reaction. The antigens may be tubular cells cytoplasm, this reaction damage to renal tubules and lead to renal tubular acidosis.