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血小板有丰富的单胺氧化酶(MAO)活力。临床上现已能测定体内的血小板MAO活力,作为测定苯乙肼和其他MAO抑制剂血浓度的指标,因而重新引起了对这些药物的兴趣。目前,直接测定苯乙肼血浓度尚无实用价值,因其血浓度低,且其与细胞中酶的结合是不可逆的。以往,作者曾双盲对照观察苯乙肼治疗60例忧郁症,分内源性和非内源性两组;剂量每天60毫克,疗程6周。对疑病、激动、
Platelets are rich in monoamine oxidase (MAO) activity. It has now been clinically possible to determine the platelet MAO viability in vivo as an indication of the blood concentrations of phenelzine and other MAO inhibitors, thus rekindling interest in these drugs. At present, the direct determination of phenelzine blood concentration has no practical value, because of its low blood concentration, and its combination with the enzyme in the cell is irreversible. In the past, the authors have double-blind control of phenelzine treatment of 60 cases of depression, endogenous and non-endogenous groups; dose 60 mg daily for 6 weeks. To suspect, excited,