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用药动学-药效学结合模型,对犬静脉推注关附甲素后,进行了药代动力学和药效动力学分析。以QTc延长百分率为效应指标,关附甲素的E_(max)、S、K_(co)和EC_(50)分别为1.11±0.01,1.06±0.43,0.097±0.046 min~(-1)和1.50×10~(-6)±0.92×10~(-6)μg/ml。
The pharmacokinetics and pharmacodynamics analysis was performed after the injection of Guansutropin in the canine pharmacokinetics and pharmacodynamics model. With QTc elongation percentage as the effect index, E_(max), S, K_(co), and EC_(50) of Guansulin were 1.11±0.01, 1.06±0.43, 0.097±0.046 min~(-1), and 1.50, respectively. ×10~(-6)±0.92×10~(-6)μg/ml.