论文部分内容阅读
目的探讨食管鳞状细胞癌(ESCC)组织中TWIST1对上皮间质转化(EMT)相关蛋白的调控作用。方法采用免疫组化法检测50例ESCC组织中TWIST1、上皮钙黏蛋白(EC)、神经钙黏蛋白(NC)和波形蛋白(V)的表达,分析TWIST1与EC、NC、V之间的关系。结果 TWIST1、EC、NC和V在ESCC组织中的阳性表达率分别为50.0%、38.0%、48.0%和52.0%。ESCC组织中TWIST1表达与EC表达呈负相关(r=-0.371,P<0.01),与V表达呈正相关(r=0.480,P<0.01),而与NC不存在明显相关性(r=0.240,P>0.05)。结论 TWIST1在ESCC中可能通过抑制EC表达、上调V表达而参与EMT过程的调节。
Objective To investigate the regulatory effect of TWIST1 on epithelial-mesenchymal transition (EMT) -related proteins in esophageal squamous cell carcinoma (ESCC). Methods The expressions of TWIST1, EC, NC and V in 50 cases of ESCC were detected by immunohistochemistry. The relationship between TWIST1, EC, NC and V was analyzed . Results The positive rates of TWIST1, EC, NC and V in ESCC tissues were 50.0%, 38.0%, 48.0% and 52.0%, respectively. The expression of TWIST1 in ESCC was negatively correlated with EC (r = -0.371, P <0.01), and positively correlated with V expression (r = 0.480, P <0.01) P> 0.05). Conclusion TWIST1 may be involved in the regulation of EMT by inhibiting EC expression and up-regulating V expression in ESCC.