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目的探讨血液灌流联合血液透析滤过治疗高脂血症性急性胰腺炎的疗效。方法将近两年收治的31例高脂血症性急性胰腺炎随机分为血液灌流联合血液透析滤过组(16例)、对照组(15例),对照组给予一般常规治疗,血液灌流联合血液透析滤过组在对照组的基础之上加用血液灌流联合血液透析滤过治疗。监测各组患者血清甘油三酯水平、氧合指数,肌酐、C反应蛋白、总住院时间。结果两组患者血清甘油三酯、血肌酐、C反应蛋白均降低,氧合指数均升高,血液灌流联合血液透析滤过组四项指标改善明显优于对照组,差异有统计学意义P<0.05;与对照组相比患者总住院时间明显减少,差异有统计学意义P<0.05。结论血液灌流联合血液透析滤过治疗高脂血症性胰腺炎能取得更优的疗效,能更有效降低甘油三酯水平。
Objective To investigate the therapeutic effect of hemoperfusion and hemodiafiltration on hyperlipidemic acute pancreatitis. Methods 31 cases of acute hyperlipidemic acute pancreatitis admitted in recent two years were randomly divided into hemodialysis group (n = 16), control group (n = 15) and control group. The patients in the control group were treated with hemoperfusion combined with blood Dialysis filtration group in the control group based on the plus hemoperfusion combined with hemodiafiltration therapy. Serum triglyceride levels, oxygenation index, creatinine, C-reactive protein and total length of hospital stay were monitored in each group. Results Serum triglyceride, serum creatinine and C-reactive protein decreased and oxygenation index increased in both groups. The improvement of four indexes in hemoperfusion and hemodiafiltration group was significantly better than that in control group, the difference was statistically significant (P < 0.05; Compared with the control group, the total hospital stay significantly reduced, the difference was statistically significant (P <0.05). Conclusion Hemoperfusion combined with hemodiafiltration in the treatment of hyperlipidemic pancreatitis can achieve better curative effect and reduce the level of triglyceride more effectively.