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目的:探讨衰弱对老年急性冠脉综合征(ACS)患者短期预后的影响。方法:选择2015年8月1日至2015年12月31日在我院老年医学中心住院的181例ACS患者为研究对象。全面评估患者临床特征和合并症情况,采用国际老年营养学会提出的简易虚弱问卷(FRAIL)评估患者的衰弱情况,并根据评估结果将患者分为衰弱组(n=108)和非衰弱组(n=73)。采用门诊随访和电话随访的方式进行3个月随访,分析衰弱对ACS患者预后的影响。结果:共有181例患者纳入研究,随访率100%,其中衰弱患者108例(59.67%)。随访期两组患者再住院、全因死亡和再发急性心肌梗死等随访终点事件发生率比较,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果提示衰弱是老年ACS患者短期再住院、全因死亡和再发急性心肌梗死的独立风险因素(OR=3.286,4.976,4.346;P=0.032,0.022,0.012)。结论:衰弱是老年ACS患者再住院、全因死亡和再发急性心肌梗死等短期预后的独立风险因素。
Objective: To investigate the effect of frailty on the short-term prognosis of elderly patients with acute coronary syndrome (ACS). METHODS: A total of 181 ACS patients hospitalized at our Geriatric Center from August 1, 2015 to December 31, 2015 were selected as the study subjects. A comprehensive evaluation of the clinical characteristics and complications of the patients was conducted. The frailty of the patients was assessed by the simple frailty questionnaire (FRAIL) proposed by the International Association for Aging Nutrition. The patients were divided into two groups based on the results: the weak group (n = 108) and the non-weak group = 73). Follow-up and follow-up by telephone follow-up of 3 months follow-up analysis of the impact of weakness on the prognosis of patients with ACS. RESULTS: A total of 181 patients were enrolled in the study, with a follow-up rate of 100%, of whom 108 were debilitated (59.67%). During the follow-up period, the incidence of rehospitalization, all-cause death and recurrent acute myocardial infarction were statistically significant (P <0.05). Multivariate logistic regression analysis indicated that debilitation was an independent risk factor for short-term readmission, all-cause death and recurrent acute myocardial infarction in elderly ACS patients (OR = 3.286, 4.976, 4.346; P = 0.032,0.022,0.012). Conclusion: Weakness is an independent risk factor for short-term prognosis such as rehospitalization, all-cause death and recurrent acute myocardial infarction in elderly patients with ACS.