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目的观察奥美拉唑联合莫沙必利治疗反流性食管炎(RE)的临床疗效。方法 96例RE患者随机分为对照组和观察组各48例,对照组给予奥美拉唑空腹口服,20 mg/次,早晚各1次。观察组在对照组同样用药的基础上,给予莫沙必利餐前口服,5 mg/次,每天3次。疗程均为8周。对比两组的治疗效果及不良反应。结果观察组有效率为93.8%,明显高于对照组(70.8%),差异有统计学意义(P<0.05)。内镜下检查食管黏膜病变,观察组有效率(89.6%)明显高于对照组(64.6%),差异有统计学意义(P<0.05)。两组患者的药物不良反应率差异无统计学意义(P>0.05)。结论奥美拉唑与莫沙比利联合使用治疗反流性食管炎疗效显著,安全性高,值得在临床推广。
Objective To observe the clinical efficacy of omeprazole combined with mosapride in the treatment of reflux esophagitis (RE). Methods 96 cases of RE patients were randomly divided into control group and observation group of 48 cases, the control group orally given omeprazole oral, 20 mg / time, morning and evening 1. Observation group in the control group on the basis of the same medication, given mosapride orally before meals, 5 mg / time, 3 times a day. The course of treatment is 8 weeks. Comparison of the two groups of treatment and adverse reactions. Results The effective rate of the observation group was 93.8%, which was significantly higher than that of the control group (70.8%), the difference was statistically significant (P <0.05). Endoscopic examination of esophageal mucosal lesions, observation group, the effective rate (89.6%) was significantly higher than the control group (64.6%), the difference was statistically significant (P <0.05). There was no significant difference in ADR between the two groups (P> 0.05). Conclusion Omeprazole combined with mosapride in the treatment of reflux esophagitis has a significant effect, high safety and is worthy of clinical promotion.