论文部分内容阅读
[目的 ]探讨晚期恶性黑色素瘤有效的治疗手段。 [方法 ]31例晚期恶性黑色素瘤采用白细胞介素 Ⅱ配合以氮烯咪胺 (DTIC)为主DDAVC方案联合化疗 (治疗组 ) ,31例晚期恶性黑色素瘤采用DDAVC方案化疗 (对照组 ) ,比较两组的疗效、毒副反应、免疫水平。 [结果 ]治疗组有效率 6 7 8% ,显著优于对照组有效率 4 1 9% (P <0 0 5 )。白细胞介素 Ⅱ免疫治疗的患者在化疗一周后免疫水平继续提高和没有免疫治疗的对照组一周后明显下降相比较有显著差异 (P <0 0 5 )。治疗组化疗骨髓抑制低于对照组。 [结论 ]白细胞介素 Ⅱ免疫配合氮烯咪胺为主联合化疗的综合治疗晚期恶性黑色素瘤可以达到预期的疗效。
[Objective] To investigate the effective treatment of advanced malignant melanoma. [Method] Thirty-one patients with advanced malignant melanoma were treated with DDAC combined with prednisolone (DTIC) plus chemotherapy (treatment group) and 31 patients with advanced malignant melanoma with DDAVC chemotherapy (control group). The two groups of curative effects, side effects, immune level. [Results] The effective rate of the treatment group was 67.8%, which was significantly better than that of the control group (41%, P <0.05). Interleukin II immunotherapy patients in the week after chemotherapy, immune levels continued to increase and no immunotherapy control group after a week decreased significantly (P <0 05). The treatment group chemotherapy bone marrow suppression than the control group. [Conclusion] Interleukin II immunization combined with daclimide combined with chemotherapy can achieve the desired effect in the treatment of advanced malignant melanoma.