用放射配体结合分析，测定了４１例（男１６例，女２５例）原发性癫痫患者外周血白细胞糖皮质激素受体（ｇｌｕｃｏｃｏｒｔｉｃｏｉｄｒｅｃｅｐｔｏｒＧＲ），同时用放射免疫分析测定了患者血浆皮质醇（Ｆ），即糖皮质激素（ｇｌｕｃｏｃｏｒｔｉｃｏｉｄＧＣ），并与正常对照组比较。结果表明，无论年龄、性别及服用何种抗痫药物，原发性癫痫患者的ＧＣ都明显高于对照组（Ｐ＜０．０１）；ＧＲ都明显低于对照组，（Ｐ＜０．０１）。鉴于ＧＣ对中枢神经系统有增强兴奋性的效应，故认为本病存在ＧＣ—ＧＲ系统异常。ＧＣ增高，ＧＲ降低可能在原发性癫痫的发生，发展中起一定作用。 Radioligand binding assay was used to determine the leukocyte glucocorticoid receptorGR in 41 patients (16 males and 25 females) and the levels of plasma cortisol (F ), Glucocorticoid GC, and compared with the normal control group. The results showed that regardless of age, sex and taking what type of anti-epileptic drugs, GC of patients with primary epilepsy were significantly higher than the control group (P <0.01); GR were significantly lower than the control group (P <0.01 ). GC in view of the central nervous system has enhanced the excitatory effect, it is considered the existence of GC-GR system abnormalities. GC increased, decreased GR may play an important role in the occurrence and development of primary epilepsy.