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目的:观察银杏叶提取物761(EGB761)对实验性肾病综合征的疗效,并探讨其可能机制。方法:实验大鼠复制成阿霉素(ADR)肾病(NS)模型,分为正常组、模型组、模型+EGB761组(EGB761组)。结果:(1)EGB761组尿蛋白量下降幅度显著高于模型组(P<0.05)。(2)实验8周末,EGB761组血清总蛋白(TP)、白蛋白(Alb)升高幅度显著高于模型组(P<0.05);EGB761组血清总胆固醇(TC)、总甘油三酯(TG)、低密度脂蛋白(LDL)下降水平均显著高于模型组(P<0.05)。(3)模型组血清总超氧化物歧化酶(SOD)显著低于正常组;丙二醛(MDA)显著高于正常组(P<0.05);EGB761组总SOD升高水平及MDA下降水平均显著高于模型组。(4)24h尿蛋白量与血清总SOD呈直线负相关,r=-0.923(P<0.01);24h尿蛋白量与血清MDA呈直线正相关,r=0.774(P<0.01)。结论:EGB761能显著改善NS大鼠临床指标,其减轻尿蛋白的作用与清除氧自由基、降血脂有关。
Objective: To observe the effect of Ginkgo biloba extract 761 (EGB761) on experimental nephrotic syndrome and its possible mechanism. METHODS: The experimental rats were duplicated into adriamycin (ADR) nephropathy (NS) model and divided into normal group, model group and model +EGB761 group (EGB761 group). Results: (1) The decrease of urine protein in EGB761 group was significantly higher than that in model group (P<0.05). (2) At the 8th week of the experiment, the serum total protein (TP) and albumin (Alb) levels in the EGB761 group were significantly higher than those in the model group (P<0.05); the serum total cholesterol (TC) and total triglyceride (TG) in the EGB761 group ), low density lipoprotein (LDL) decreased significantly higher than the model group (P <0.05). (3) The serum total superoxide dismutase (SOD) in the model group was significantly lower than that in the normal group; malondialdehyde (MDA) was significantly higher than the normal group (P<0.05); the total SOD level and the MDA decreased level in the EGB761 group. Significantly higher than the model group. (4) 24h urinary protein was negatively correlated with serum total SOD, r=-0.923 (P<0.01); 24h urine protein was positively correlated with serum MDA, r=0.774 (P<0.01). Conclusion: EGB761 can significantly improve the clinical parameters of NS rats. The effect of reducing urinary protein is related to scavenging oxygen free radicals and lowering blood lipids.