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目的探讨人表皮生长因子受体2(Her-2/neu)在胃癌组织中的表达及与胃癌生物学行为和预后的相关关系。方法采用SP免疫组化技术检测158例胃癌及其癌旁组织中Her-2/neu蛋白的表达,将检测结果与胃癌临床病理参数及患者随访资料进行相关性分析。结果 158例胃癌组织中,Her-2/neu蛋白阳性表达率为26.58%(42/158),癌旁正常胃组织中均未见Her-2/neu蛋白的阳性表达;Her-2/neu蛋白表达与肿瘤的浸润深度、病理分期、淋巴结转移、脉管神经受累及患者生存时间相关(P<0.05),但与患病年龄、性别、肿瘤大小及肿瘤部位无相关性(P>0.05)。Her-2/neu蛋白阳性表达的胃癌患者中位生存时间及生存率均明显低于Her-2/neu蛋白阴性者(P<0.05)。结论 Her-2/neu蛋白表达与胃癌生物学行为密切相关;检测Her-2/neu表达对胃癌临床预后评估及其治疗的选择有一定的指导意义。
Objective To investigate the relationship between the expression of Her-2 / neu and its biological behavior and prognosis in gastric cancer. Methods The immunohistochemical SP method was used to detect the expression of Her-2 / neu protein in 158 cases of gastric cancer and its adjacent tissues. The correlation between the results and clinical pathological parameters and follow-up data was analyzed. Results The positive expression rate of Her-2 / neu protein was 26.58% (42/158) in 158 cases of gastric cancer tissues, and no positive expression of Her-2 / neu protein was found in normal gastric cancer tissues. The expression was related to the depth of invasion, pathological stage, lymph node metastasis, vascular nerve involvement and patient survival time (P <0.05), but not with the age, sex, tumor size and tumor location (P> 0.05). The median survival time and survival rate of patients with Her-2 / neu protein positive gastric cancer were significantly lower than those with negative Her-2 / neu protein (P <0.05). Conclusions The expression of Her-2 / neu is closely related to the biological behavior of gastric cancer. The detection of Her-2 / neu expression may be helpful for the clinical prognosis evaluation and treatment of gastric cancer.