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目的:观察川芎嗪注射液穴位注射对缺血性脑中风模型大鼠脑梗死比例及行为学评分的影响,探讨川芎嗪注射液穴位注射治疗缺血性脑中风的优势性。方法:采用线栓法建立大脑中动脉缺血模型(MCAO),将大鼠随机分为假手术组、模型组、肌肉注射组、静脉注射组、穴位注射组、阳性对照组,缺血再灌注4 h后给药3次,末次给药1 h后,通过TTC染色检测脑梗死比例并评定大鼠的行为学评分。结果:川芎嗪注射液可以明显降低MCAO大鼠病灶侧脑梗死比例(P<0.05),其中穴位注射组优于肌肉注射组及静脉注射组。川芎嗪穴位注射组大鼠行为学评分低于模型组(P<0.05)。结论:川芎嗪注射液穴位注射可降低缺血性脑中风模型大鼠脑梗死比例及行为学评分,川芎嗪注射液治疗缺血性脑中风具有穴位特异性优势。
OBJECTIVE: To observe the effect of ligustrazine injection on the proportion of cerebral infarction and the score of behavior in ischemic stroke model rats, and to investigate the advantage of ligustrazine injection in the treatment of ischemic stroke. Methods: The middle cerebral artery occlusion model (MCAO) was established by thread occlusion. The rats were randomly divided into sham operation group, model group, intramuscular injection group, intravenous injection group, acupoint injection group, positive control group, ischemia reperfusion After 4 h, the drug was administered three times. After the last administration, the proportion of cerebral infarction was detected by TTC staining and the behavioral score of the rats was assessed. Results: Ligustrazine injection significantly reduced the proportion of lateral cerebral infarction in MCAO rats (P <0.05), and acupoint injection group was superior to intramuscular injection group and intravenous injection group. Ligustrazine acupoint injection group rats behavioral score was lower than model group (P <0.05). Conclusion: Ligustrazine injection acupoint injection can reduce cerebral infarction rate and behavioral score in ischemic stroke model rats. Ligustrazine injection has the advantage of acupoint specificity in the treatment of ischemic stroke.