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目的了解广西巴马地区居民血清沉默信号调节蛋白6(silent information regulator 6,SIRT6)蛋白表达水平的差异,探讨其与家庭聚集性长寿现象的关系。方法于2011年5—6月,在巴马地区单纯随机抽取有3~4代直系亲属的家庭分为长寿家族史组共137例(年龄30~106岁,男70人,女67人)和非长寿家族史组共91例(年龄22~89岁,男51人,女40人)。测定血压、血生化指标[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖(FPG)]和血清SIRT6蛋白表达水平。结果长寿家族史组血清TC、TG和HDL含量均低于非长寿家族史组(P<0.05,P<0.01)。长寿家族史组血清中SIRT6表达水平低于非长寿家族史组(P<0.05)。经单因素分析,长寿家族史组血清SIRT6蛋白水平与年龄、FPG含量呈正相关(P<0.05),与TG含量呈负相关(P<0.05);而非长寿家族史组血清SIRT6蛋白水平仅与年龄呈负相关(P<0.05)。结论血清SIRT6蛋白表达水平可能与巴马地区家庭聚集性长寿现象存在一定联系。
Objective To investigate the differences of serum expression of silent information regulator 6 (SIRT6) in residents of Bama region of Guangxi and to investigate their relationship with familial aggregation and longevity. Methods From May to June 2011, 137 families (aged 30 to 106 years, 70 males and 67 females) with a family history of 3 to 4 generations randomly selected from the Bama region were randomly divided into three groups: Non-longevity family history of a total of 91 cases (aged 22 to 89 years, 51 males and 40 females). Blood pressure, blood biochemical markers of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), fasting plasma glucose (FPG) and serum SIRT6 protein were measured. Results The serum levels of TC, TG and HDL in the longevity family history group were lower than those in the non-longevity family history group (P <0.05, P <0.01). The serum levels of SIRT6 in the longevity family history group were lower than those in the non-longevity family history group (P <0.05). By univariate analysis, the serum SIRT6 protein level in the longevity family history group was positively correlated with age and FPG content (P <0.05), and negatively correlated with the TG content (P <0.05); while the serum SIRT6 protein level in the non-longevity family history group was only Age was negatively correlated (P <0.05). Conclusion Serum SIRT6 protein expression may be related to the phenomenon of familial aggregation and longevity in the Bama region.