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目的探讨成人缓发性自身免疫性糖尿病(LADA)临床特征及与2型糖尿病患者的差异。方法对40例缓发性自身免疫性糖尿病、30例1型糖尿病、128例2型糖尿病及100例健康对照者进行身高、体重、血糖、糖化血红蛋白、胰岛素、C肽、血脂、血尿酸等水平检测。结果LADA患者体重指数、糖化血红蛋白、空腹血糖、C肽、餐后血糖、刺激后C肽、胰高血糖素、总胆固醇、高密度胆固醇、低密度胆固醇、甘油三酯及血尿酸水平分别为(21.73±3.96)kg/m2、(8.72±1.92)%、(16.87±6.70)mmol/L、(23.79±8.77)mmol/L、(0.50±0.30)nmol/L、(0.90±0.50)nmol/L、(84.12±7.31)pg/dl、(4.79±0.98)mmol/L、(1.08±0.53)mmol/L、(3.37±1.03)mmol/L、(1.89±1.03)mmol/L及(269.48±76.11)μmol/L,多数指标介于T1DM与T2DM水平之间。结论在表型方面LADA患者明显有别于T2DM患者。
Objective To investigate the clinical features of adults with delayed-onset autoimmune diabetes (LADA) and their differences with those of type 2 diabetes mellitus (T2DM). Methods The body weight, blood glucose, glycosylated hemoglobin, insulin, C-peptide, blood lipid and serum uric acid were measured in 40 patients with delayed-onset autoimmune diabetes, 30 with type 1 diabetes, 128 with type 2 diabetes and 100 healthy controls Detection. Results The body mass index, glycosylated hemoglobin, fasting blood glucose, C peptide, postprandial blood glucose, C peptide, glucagon, total cholesterol, high density cholesterol, low density cholesterol, triglyceride and serum uric acid in LADA patients were 21.73 ± 3.96 kg / m2, 8.72 ± 1.92%, 16.87 ± 6.70 mmol / L, 23.79 ± 8.77 mmol / L, 0.50 ± 0.30 nmol / L and 0.90 ± 0.50 nmol / L respectively , (84.12 ± 7.31) pg / dl, (4.79 ± 0.98) mmol / L, (1.08 ± 0.53) mmol / L, (3.37 ± 1.03) mmol / L and (1.89 ± 1.03) mmol / L and (269.48 ± 76.11 ) μmol / L, most of the indicators between T1DM and T2DM levels. Conclusion LADA patients are significantly different from T2DM patients in terms of phenotype.