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目的对比分析米索前列醇联合催产素治疗择期剖宫产术后出血的临床疗效及安全性。方法将2010年1月-2012年10月在我院就诊的择期剖宫产孕妇80例,随机分为实验组和对照组,每组各40例。实验组使用米索前列醇联合催产素的方法预防剖宫产术后出血,对照组采取单用催产素的方法预防剖宫产术后出血,记录、称量术中出血量及术后24小时出血量,观察患者有无术后并发症的发生。结果实验组术中出血量为(189.52±29.56)ml,与对照组的术中出血量(176.65±32.92)ml比较,P>0.05,没有统计学差异;实验组的术后2h出血量为(132.52±39.58)ml,术后2-24h出血量为(40.52±5.63)ml,对照组的术后2h出血量为(298.75±65.32)ml,术后2-24h出血量为(102.36±10.86)ml,组间术后2h出血量、术后2-24h出血量比较,P<0.05差异具有统计学意义。各组均无严重的并发症发生。结论米索前列醇联合催产素治疗择期剖宫产术后出血的临床效果好,安全性高,值得临床推广使用。
Objective To compare and analyze the clinical efficacy and safety of misoprostol combined with oxytocin in the treatment of post-cesarean section hemorrhage. Methods Eighty pregnant women with elective cesarean section in our hospital from January 2010 to October 2012 were randomly divided into experimental group and control group, 40 cases in each group. The experimental group used misoprostol combined with oxytocin to prevent bleeding after cesarean section, the control group to take a single oxytocin method to prevent bleeding after cesarean section, record, weighed intraoperative blood loss and 24 hours after operation Bleeding, observation of patients with or without postoperative complications. Results The blood loss in the experimental group was (189.52 ± 29.56) ml, which was significantly higher than that in the control group (176.65 ± 32.92) ml, P> 0.05. There was no significant difference between the two groups in the experimental group 132.52 ± 39.58) ml, the amount of bleeding was (40.52 ± 5.63) ml at 2-24h after operation, the amount of bleeding at 2h after operation was (298.75 ± 65.32) ml in control group, and the amount of bleeding was (102.36 ± 10.86) ml, 2h postoperative bleeding volume, postoperative 2-24h bleeding volume comparison, P <0.05 difference was statistically significant. No severe complications occurred in all groups. Conclusion The combination of misoprostol and oxytocin in the treatment of postoperative elective cesarean section has a good clinical effect and high safety, which is worthy of clinical promotion.