本文报告1例受链格孢感染、病程很长的53岁女性患者,其鼻咽、筛窦、鼻甲、鼻中隔及鼻外部的软组织均受到侵犯.最早期的表现为反复发生筛窦炎,接着腭部出现烧灼感并迅速发生溃疡以及硬腭向鼻根部穿孔.活检证实为链格孢属真菌.虽曾使用制霉菌素、二性霉素B、酮康唑、伊他康唑及其 This article reports a case of 53-year-old female patient infected with Alternaria and having a long course of disease with infiltration of the nasopharynx, ethmoid sinus, nasal turbinate, nasal septum and external nasal soft tissue. The earliest manifestations were recurrence of ethmoid sinusitis followed by The palate showed a burning sensation and ulceration quickly and the palate pierced the nasal root. Biopsy was confirmed as Alternaria fungus. Although nystatin, amphotericin B, ketoconazole, itraconazole and its