无论是在体外实验、还是在体内实验,MSCs都可以向中枢神经系统(CNS)神经细胞分化,但争议颇多。因为功能性神经元不仅要具有典型神经元的形态、特异性标记,还要求具有可兴奋性、能和其他神经元形成突触联系、产生突触电位等,所以对于骨髓间充质干细胞是否能诱导出真正具有功能的神经元存在很大分歧。在此对MSCs向神经细胞诱导分化研究的现况、存在的问题及发展前景给以综述。 Whether in vitro experiments or in vivo experiments, MSCs can differentiate to the central nervous system (CNS) neurons, but a lot of controversy. Because functional neurons not only have the morphological and specific markers of typical neurons, they also require excitability, synaptic connections with other neurons, synaptic potentials, and the like, whether or not functional neurons can function as bone marrow mesenchymal stem cells There is a big difference between inducing truly functional neurons. In this paper, the status of MSCs to differentiate into neural cells, the existing problems and prospects for development are reviewed.