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目的 :研究黄参膏对晚期肝癌患者生活质量的影响。方法 :12 5例晚期肝癌患者随机分为两组 ,两组均给予一般对症、护肝治疗 ;治疗组加口服黄参膏 2 0 m l,3次 / d,2个月为 1个疗程 ,记录治疗前后两组患者的肿瘤直径、静脉癌栓、远处转移、行为状态评分 (采用 Karnofsky评分标准 )及生存时间。结果 :治疗组服药 2个月后肿瘤直径较治疗前无明显变化 (P>0 .0 5 ) ,对照组 2个月后肿瘤直径明显增大 (P<0 .0 1) ;合并静脉癌栓及远处转移例数对照组明显多于治疗组 (均 P<0 .0 5 ) ;治疗组行为状态评分较用药前明显增高 (P<0 .0 1) ,对照组明显下降(P<0 .0 1) ;患者生存时间治疗组较对照组明显延长 (P<0 .0 1)。结论 :黄参膏可能是一种较为理想的中药抗肿瘤制剂 ,能提高晚期肝癌患者的生活质量。
Objective: To study the effect of Huangshen Paste on quality of life in patients with advanced liver cancer. Methods: One hundred and twenty-five patients with advanced hepatocellular carcinoma were randomly divided into two groups. The two groups were given general symptomatic and hepatoprotective therapy. The treatment group was given oral ginseng 20 ml 3 times daily for 2 months as a course of treatment. Tumor diameter, vein thrombosis, distant metastasis, behavior status scores (using Karnofsky score) and survival time of the two groups before and after treatment. Results: The tumor diameter of the treatment group after 2 months of treatment had no significant change (P> 0.05), and the diameter of the tumor in the control group increased significantly after 2 months (P <0.01) (P <0.05). The score of behavioral status in the treatment group was significantly higher than that in the control group (P <0.01), while the control group was significantly decreased (P <0. 05) .0 1). The survival time of patients in treatment group was significantly longer than that in control group (P <0.01). Conclusion: Huangshen cream may be an ideal Chinese medicine antitumor agents, can improve the quality of life of patients with advanced liver cancer.