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目的研究老年血糖异常患者血清胆红素的变化及影响血糖水平的危险因素。方法纳入住院老年患者644例,其中血糖异常患者303例(血糖异常组),血糖正常患者341例(对照组)。记录所有研究对象的一般情况及各项指标,包括胆红素、肝功能、血脂、C反应蛋白(CRP)、脑钠肽(BNP)等,进行相应统计学分析。结果与对照组相比,血糖异常组患者血清总胆红素(TB)、间接胆红素(IB)水平降低(P<0.05),血清CRP水平升高(P<0.01)。按血清总胆红素四分位数分组,胆红素高水平组比胆红素低水平组血糖、血压水平异常的百分比低(P=0.000,P=0.016)。有无血糖异常及血糖异常的严重程度与血清TB、IB水平呈弱负相关(P<0.05)。结论在老年人群中,生理范围内轻度升高的胆红素可能是血糖异常的一个保护因素。
Objective To study the changes of serum bilirubin and the risk factors influencing blood glucose level in elderly patients with abnormal glucose. Methods A total of 644 hospitalized elderly patients were enrolled, including 303 patients with abnormal blood glucose (dyslipidemia group) and 341 patients with normal blood glucose (control group). The general situation and indicators of all the subjects were recorded, including bilirubin, liver function, blood lipids, C-reactive protein (CRP), brain natriuretic peptide (BNP) and so on. Results Compared with the control group, the levels of serum total bilirubin (TB), indirect bilirubin (IB) and serum CRP levels were significantly lower in patients with abnormal glucose (P <0.01). According to the serum total bilirubin quartiles, the percentage of abnormal high blood glucose and blood pressure levels in the high bilirubin group was lower than that in the low bilirubin group (P = 0.000, P = 0.016). The presence or absence of abnormal blood glucose and the severity of abnormal blood glucose and serum TB, IB levels were weakly negative correlation (P <0.05). Conclusion In the elderly population, slightly elevated bilirubin in the physiological range may be a protective factor of abnormal blood glucose.