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胶原性结肠炎(collagenous colitis,CC)是一种以水泻为表现的临床病理综合征,内镜检查无异常。作者采用的诊断标准为:1.上皮下有胶原层沉着(此胶原层正常厚度为3μm);2,保存隐窝结构;3.粘膜的慢性非特异性炎症;4.表层上皮有炎症细胞浸润。镜下结肠炎(microscopic colitis,MC)则为慢性腹泻患者的结肠粘膜轻度弥漫性炎症,具有正常内镜下外观,钡灌肠正常。组织学上固有层可有轻度的以浆细胞为主的慢性炎症细胞增多,杯状细胞分泌粘液轻度减少,表层上皮单个核或多形核细胞增多。
Collagenous colitis (CC) is a clinicopathologic syndrome characterized by watery diarrhea, with no abnormal endoscopy. The diagnostic criteria used by the authors are: 1. Collagen layer under the epithelium calm (the normal thickness of the collagen layer is 3μm); 2, preservation of crypt structure; 3. mucosal chronic non-specific inflammation; 4. Epithelial inflammatory cell infiltration. Microscopic colitis (MC) is a mild and diffuse inflammation of colonic mucosa in patients with chronic diarrhea, with normal endoscopic appearance and normal barium enema. Histologically, the lamina propria may have a mild increase in chronic inflammatory cells predominantly of plasma cells, a slight decrease of goblet cell secreting mucus and an increase of single or polymorphonuclear cells in the surface epithelium.