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宫颈癌是全世界妇女最常见的恶性肿瘤。人乳头状瘤病毒(HPV)被认为是导致宫颈癌前期病变和恶变的主要原因,尤其是高风险的HPV16和18型。高风险HPV相关的原癌蛋白E6和E7在宫颈癌的发生、发展中起重要作用。然而,从最初的病毒感染到宫颈癌的发生需要经历漫长的过程,提示多步骤(从CIN到肿瘤发生)、多因素(性生活、吸烟、口服避孕药)参与了宫颈癌的发生、发展。本文就病毒的原癌蛋白与宿主的细胞蛋白的相互作用,以及这种作用对宫颈癌发生、发展的影响进行简要综述。
Cervical cancer is the most common malignancy in women worldwide. Human papilloma virus (HPV) is considered to be the leading cause of precancerous and malignant cervical precancerous lesions, especially at high risk of HPV types 16 and 18. High-risk HPV-associated oncoproteins E6 and E7 play an important role in the development and progression of cervical cancer. However, from the initial virus infection to the occurrence of cervical cancer takes a long process, suggesting that multiple steps (from CIN to tumorigenesis), multiple factors (sex life, smoking, oral contraceptives) involved in the occurrence and development of cervical cancer. In this paper, the proto-oncogene protein and host cell protein interactions, and this effect on the occurrence and development of cervical cancer are briefly reviewed.