论文部分内容阅读
为研究组织蛋白酶Ｄ（Ｃａｔｈ Ｄ） 在慢性肝病（ＣＬＤｓ）和肝癌（ＰＨＣ） 中的表达及意义。以兔抗人Ｃａｔｈ Ｄ抗体免疫组化法。结果显示ＣＡＨ 和ＣＨＣａｔｈ Ｄ 阳性率及表达强度高于正常肝和ＣＰＨ，但明显低于ＰＨＣ；高分化、淋巴结未转移和肿块最大径≤５ｃｍ 组ＰＨＣＣａｔｈ Ｄ 阳性表达率和强度均明显低于低分化、淋巴结转移和肿块最大径＞ ５ｃｍ 组ＰＨＣ。结论Ｃａｔｈ Ｄ 可能是一个反映ＰＨＣ发生发展、生物学行为和预后的重要标记物。
To study the expression of cathepsin D (Cath D) in chronic liver disease (CLDs) and hepatocellular carcinoma (PHC) and its significance. Rabbit anti-human Cath D antibody immunohistochemistry. The results showed that the positive rates of CAH and CHCath D were significantly higher than those of normal liver and CPH, but significantly lower than that of PHC. The positive rate and intensity of PHCCath D in well differentiated, non-metastatic lymph nodes and the largest diameter ≤5cm group were significantly lower than those in poorly differentiated , Lymph node metastasis and tumor maximum diameter> 5cm group PHC. Conclusions Cath D may be an important marker of PHC development, biological behavior and prognosis.