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吡硫醇锌(ZPT)急性毒性实验,小鼠灌胃和腹腔注射LD_(60)分别为260mg/k9和22.5mg/kg。中毒症状一致,呼吸抑制可能致死的主因。ZPT长期毒性实验,大鼠与犬的毒性反应基本相同,服药后出现食欲减退和体退减轻。心肝肾功能均正常。病理学检查大剂量组部分动物发生肝浊肿,空泡变。局部应用有轻度刺激性。结果表明ZPT外用是安全的。
Acute toxicity experiments of zinc pyrithione (ZPT) showed that the LD_ (60) were intragastrically and intraperitoneally injected to 260 mg / kg and 22.5 mg / kg, respectively. The same symptoms of poisoning, respiratory depression may be the main cause of death. ZPT long-term toxicity test, rat and dog toxicity is basically the same, after taking the appetite decreased and body remission. Heart, liver and kidney function are normal. Pathological examination of high-dose group of some animals liver turbidity, vacuolar change. Topical mild irritation. The results show that ZPT for external use is safe.