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目的 :检测食管鳞状细胞癌组织中细胞胀亡及血管内皮生长因子 (VEGF)的表达。方法 :利用透射电镜和免疫组织化学技术检测 30例食管鳞状细胞癌组织中细胞胀亡指数及VEGF表达情况 ,分析 2者的相关性。结果 :VEGF阳性的细胞很少发生细胞胀亡 ,VEGF高表达的癌组织中较少存在细胞胀亡。食管鳞状细胞癌组织中VEGF的表达与细胞胀亡的发生呈负相关 (q =7.2 6 4 ,P <0 .0 5 )。结论 :食管鳞状细胞癌组织中细胞胀亡的发生可能与新生血管缺乏有关
OBJECTIVE: To detect the cell infiltration and the expression of vascular endothelial growth factor (VEGF) in esophageal squamous cell carcinoma. Methods: The cell expansion index and VEGF expression in 30 cases of esophageal squamous cell carcinoma were detected by transmission electron microscopy and immunohistochemistry. The correlation between them was analyzed. Results: There was seldom occurrence of cell expansion in VEGF positive cells, and few in cancerous cells with high expression of VEGF. The expression of VEGF in esophageal squamous cell carcinoma was inversely correlated with the occurrence of cell death (q = 7.26 4, P <0.05). Conclusion: The occurrence of cell infiltration and apoptosis in esophageal squamous cell carcinoma may be related to the lack of neovascularization