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同源盒基因广泛存在于真核生物中 ,是转录因子中的大家族 ,具有高度的保守性 ,在个体发育和细胞分化中起重要的调控作用 ,其异常调控可导致细胞癌变。近年来对同源盒基因在乳腺发育和乳腺癌中的研究已成为探索乳腺癌发病机制的热点之一。
Homologous box genes are widely distributed in eukaryotes and are a large family of transcription factors. They are highly conserved and play an important regulatory role in individual development and cell differentiation. Abnormal regulation of them leads to canceration of cells. In recent years, homologous box gene in breast development and breast cancer research has become one of the hot spots to explore the pathogenesis of breast cancer.