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目的研究胰腺炎对肝衰竭患者血细胞、肝肾功能及预后的影响。方法以肝衰竭并发急性胰腺炎病例为研究组,回顾性分析并发胰腺炎前后血常规、肝肾功能变化情况,随机抽取同时期非并发胰腺炎的肝衰竭患者为对照组,分析两组严重并发症的发生率及病死率。结果发生急性胰腺炎后红细胞及血红蛋白明显下降(t=4.088,P=0.000;t=3.419,P=0.002),血清总胆红素明显升高(t=2.063,P=0.048),出现明显的肾功能损害,血清尿素氮、肌酐明显升高(t=3.172,P=0.004;t=3.183,P=0.004),发生急性胰腺炎增加了肝肾综合征的发生率(39.4%vs3.0%,t=13.055,P=0.000),以及病死率(69.7%vs42.4%,t=4.982,P=0.026)。结论肝衰竭并发急性胰腺炎使得病情严重,易发生肝肾综合征,病死率增高。
Objective To study the effect of pancreatitis on blood cells, liver and kidney function and prognosis in patients with liver failure. Methods Acute pancreatitis in patients with liver failure was selected as the study group. The changes of blood and liver and kidney function before and after complicated with pancreatitis were retrospectively analyzed. The patients with liver failure were randomly selected as the control group. Incidence and mortality. Results Serum total bilirubin (t = 2.063, P = 0.048) was significantly decreased after acute pancreatitis (t = 4.088, P = 0.000; t = 3.419, P = 0.002) Acute pancreatitis increased the incidence of hepatorenal syndrome (39.4% vs 3.0%) in patients with renal failure, serum urea nitrogen and creatinine (t = 3.172, P = 0.004; t = 3.183, , t = 13.055, P = 0.000), and the case fatality rate (69.7% vs42.4%, t = 4.982, P = 0.026). Conclusions Acute pancreatitis caused by liver failure makes the disease serious, prone to hepatorenal syndrome, and the mortality rate increases.