目的　研究松梅乐注射液对实验性骨折愈合的影响并探讨其可能的机制。方法　 40只日本大耳白兔制备双侧桡骨骨缺损模型 ,随机分为对照组和实验组 ,分别于骨折后予以生理盐水和松梅乐注射液静脉注射 ,每天 1次 ,连续 14d ,伤后 4周时取标本进行组织学、放射学和生物力学检测。结果　实验组动物骨痂的软骨形态学和软骨内骨形成活跃 ,软骨细胞数明显增多 (分别为1.60× 10 4/cm2 和 0 .68× 10 4/cm2 ,P <0 .0 1) ,骨折骨痂扭力试验比对照组高出 3 1% ,刚度上升49 % ,放射学愈合提前 (平均分别为 2 .1期和 1.5期 )。结论　早期应用松梅乐注射液可明显促进骨折愈合 Objective To study the effect of Songmeile injection on experimental fracture healing and explore its possible mechanism. METHODS: Forty Japanese rabbits were used to prepare the bilateral tibial bone defect model and randomly divided into control group and experimental group. The saline and Songmei injection were injected intravenously once a day for 14 days after injury. At 4 weeks, specimens were taken for histology, radiology, and biomechanics. Results The cartilage morphology and cartilage bone formation in the experimental group were active, and the number of chondrocytes was significantly increased (1.60×10 4 /cm 2 and 0.68×10 4 /cm 2 , respectively, P 0. 01). The callus torsion test was 31% higher than the control group, the stiffness increased 49%, and radiological healing was advanced (average 2.1 and 1.5 periods, respectively). Conclusion Early application of Songmeile injection can significantly promote fracture healing