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采用四条血管阻断方法制成家兔急性全脑缺血再灌流模型，观察家兔脑组织胞浆内ＳＯＤ及Ｎａ＋，Ｋ＋，Ｃａ（２＋），Ｍｇ（２＋）含量变化，结果发现家兔脑组织单纯缺血时ＳＯＤ活力明显下降（与正常对照组相比Ｐ＜０．０１），缺血再灌流后ＳＯＤ活力又较单纯缺血组进一步下降（Ｐ＜０．０１），Ｎａ＋，Ｃａ（２＋）在单纯缺血时含量增高（与正常对照组相比Ｐ＜０．０１），而Ｋ＋，Ｍｇ（２＋）则减少（Ｐ＜０．０１）；缺血再灌流后Ｎａ，Ｃａ（２＋）含量较单纯缺血组进一步增高（Ｐ＜０．０１），Ｋ＋，Ｍｇ（２＋）减少（Ｐ＜０．０１）．应用ＡＴＰ－氯化镁治疗后，上述指标与正常对照组相比无显著差异。
The rabbit model of acute global cerebral ischemia and reperfusion was established by four vascular occlusion methods. The contents of SOD and Na +, K +, Ca (2 +) and Mg (2+) in the brain tissue of rabbits were observed. Compared with normal group, the activity of SOD decreased significantly (P <0.01 compared with normal control group), the activity of SOD decreased after ischemia and reperfusion (P <0.01) (P <0.01), while K + and Mg (2+) decreased (P <0.01). After ischemia and reperfusion, the contents of Na, Ca (2+) ) Levels were significantly higher than those in ischemia group (P <0.01), while K + and Mg (2+) decreased (P <0.01). The application of ATP-magnesium chloride treatment, the above indicators compared with the normal control group no significant difference.