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目的研究大剂量乙酰半胱氨酸联合前列地尔对急性肾损伤(AKI)治疗疗效。方法选取2013年4月至2016年1月AKI患者98例,以随机数字法分为观察组和对照组,每组49例。对照组给予前列地尔注射治疗,观察组在对照组的基础上加用大剂量乙酰半胱氨酸进行治疗。对比两组治疗效果。结果观察组治愈率以及有效率分别为77.6%(38/49)、98.0%(48/49),均显著高于对照组[55.1%(27/49)、83.7%(41/49)]。此外,观察组血肌酐恢复时间及少尿期持续时间分别为(11.8±1.4)、(5.4±2.8)d,均明显低于对照组[(17.2±2.3)、(8.3±2.2)d],差异均有统计学意义(P均<0.05)。结论大剂量乙酰半胱氨酸联合前列地尔对AKI治疗疗效显著,能及时有效地缓解患者症状,降低病死率。安全性好,值得临床推广使用。
Objective To study the effect of high-dose acetylcysteine combined with alprostadil on acute kidney injury (AKI). Methods From April 2013 to January 2016, 98 patients with AKI were selected and randomly divided into observation group and control group, 49 cases in each group. The control group was given prostaglandin injection, and the observation group was treated with high-dose acetylcysteine on the basis of the control group. Compare the two groups treatment effect. Results The cure rate and effective rate of the observation group were 77.6% (38/49) and 98.0% (48/49), respectively, which were significantly higher than those in the control group [55.1% (27/49), 83.7% (41/49)]. In addition, the serum creatinine recovery time and duration of oliguria in the observation group were (11.8 ± 1.4) and (5.4 ± 2.8) days, respectively, which were significantly lower than those in the control group [(17.2 ± 2.3) and (8.3 ± 2.2) days] The differences were statistically significant (all P <0.05). Conclusion High-dose acetylcysteine combined with alprostadil has a significant therapeutic effect on AKI, which can alleviate the symptoms and reduce the mortality in time. Good safety, it is worth to promote clinical use.