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抗核抗体(ANA)是出现于全身性风湿病病人血清中的一组自身抗体,可分别与多种核成分(从核酸到酸性及碱性核蛋白)反应。一般无种属和器官特异性。对于风湿病的诊断、鉴别、处理、预后判断,测定ANA的有无及滴度高低是十分重要的,但更重要的是要鉴定ANA的免疫学特异性。一、ANA的种类及临床意义 (一)抗DNA抗体:至少有三类。(1)抗双股DNA(dsDNA);作用于DNA的双股螺
Antinuclear antibodies (ANAs) are a group of autoantibodies that appear in the serum of patients with systemic rheumatism and react with a variety of nuclear components, from nucleic acids to acidic and basic nucleoproteins. Generally without species and organ specificity. It is very important for the diagnosis, identification, treatment and prognosis of rheumatism to determine the presence or absence of ANA and the level of ANA, but more importantly, to identify the immunological specificity of ANA. First, the type of ANA and clinical significance (A) anti-DNA antibodies: at least three categories. (1) anti-double-stranded DNA (dsDNA); acting on the DNA double-stranded snails