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(一)应用五种不同方法进行的动物实验证明:吐酒石溶液(1)经胃而入肠道,则催吐潜伏期很长,(2)留在胃内不致吐,进入肠道内则迅速致吐。由此认为胃的感受器对吐酒石催吐刺激的敏感性远较肠道为差,口服吐酒石溶液的催吐作用乃刺激肠道的结果。 (二)口服吐酒石刺激肠道催吐的传入神经主要是迷走神经,较大剂量也可能刺激交感神经。 (三)氧丙嗪的较大剂量能部分地抑制口服吐酒石的反射性催吐,而对於反覆给予一种口服吐酒石制剂后所致的可能属於吸收型的催吐,小剂量的氯丙嗪已能发挥镇吐疗效。
(A) animal experiments using five different methods to prove: spit tartar solution (1) through the stomach and enter the intestine, then the emetic latency is very long, (2) stay in the stomach without vomiting, enter the intestine quickly threw up. Thus that the sensitivity of gastric receptors for spit tartar induced irritation far worse than the intestinal tract, oral vomiting tartar solution emetic effect is to stimulate the intestine. (B) oral vomiting tartar stimulated intestinal vomiting of the afferent nerve is mainly the vagus nerve, larger doses may also stimulate sympathetic. (C) The higher dose of oxprorazine can partially inhibit the reflective emetic spit from oral to tartar, whereas for repeated oral administration of toasted tartar, which may be of the absorption emetic, small dose of chlorine Promazine has been able to exert antiemetic effects.