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目的:观察氨茶碱治疗新生儿胎粪吸入综合征的相关临床指标变化。方法:将新生儿胎粪吸入综合征患儿26例随机分为观察组和对照组各13例。对照组采用常规治疗,观察组在常规治疗基础上加用氨茶碱。氨茶碱用生理盐水稀释成1 mg/mL,先分别在入院后1 h和3 h给予氨茶碱2.0 mg/kg静脉滴注,每次静脉滴注时间控制在20 min内,以后每12 h 1次,疗程3~5 d。观察两组相关临床指标的变化和疗效。结果:观察组患儿住院时间短于对照组[(9.23±1.54)d vs(10.50±1.27)d,P<0.05],吸氧时间短于对照组[(2.77±1.17)d vs(3.90±0.99)d,P<0.05],入院12 h时的呼吸频率低于对照组[(69±5)次/分vs(76±6)次/分,P<0.01],氧合指数高于对照组(214.46±55.19 vs 170.40±0.43,P<0.05),总有效率高于对照组(100.0%vs 61.5%,P<0.05)。结论:应用氨茶碱治疗新生儿胎粪吸入综合征能缩短住院及吸氧时间,改善呼吸频率和肺部氧合,且未发现明显不良反应。
Objective: To observe the changes of aminophylline in the treatment of neonatal meconium aspiration syndrome. Methods: 26 cases of neonatal meconium aspiration syndrome were randomly divided into observation group and control group, with 13 cases in each group. Control group with conventional treatment, observation group in the conventional treatment based on the use of aminophylline. Aminophylline diluted with normal saline into 1 mg / mL, first were given 1 h and 3 h after admission aminophylline 2.0 mg / kg intravenous infusion, each intravenous infusion time control in 20 min, and after every 12 h 1 times, treatment 3 ~ 5 d. Observe the change and curative effect of the two groups related clinical indexes. Results: The hospitalization time in observation group was shorter than that in control group [(9.23 ± 1.54) d vs (10.50 ± 1.27) d, P <0.05] 0.99) d, P <0.05]. The respiratory rate at 12 h after admission was lower than that of the control group (69 ± 5) / min vs (76 ± 6) bpm, P <0.01] Group (214.46 ± 55.19 vs 170.40 ± 0.43, P <0.05). The total effective rate was higher than that of the control group (100.0% vs 61.5%, P <0.05). Conclusion: The use of aminophylline in the treatment of neonatal meconium aspiration syndrome can shorten the duration of hospitalization and oxygen inhalation, improve respiratory rate and pulmonary oxygenation, and no obvious adverse reactions were found.