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目的观察金双歧联合思密达治疗小儿腹泻的临床疗效及不良反应。方法本观察88例急性腹泻患儿按随机原则分为观察组和对照组各44例,两组均给予调整饮食、ORS液口服或静脉补液,纠正水电解质紊乱,纠正酸中毒和进食指导等基础治疗,观察组在此基础上加用金双歧、思密达口服,疗程3 d。对照组加用乳酶生、复合维生素B口服,两组均根据病情给予降温、止吐等对症治疗。结果观察组显效37例(84.1%),有效6例,无效1例,总有效率为97.7%;对照组显效21例(47.7%),有效14例,无效9例,总有效率为79.5%,两组比较差异均有统计学意义(χ2=11.44,P<0.05)。治疗期间两组均无明显不良反应发生。结论金双歧联合思密达治疗小儿腹泻有相互协同作用,有利于病原微生物的排出,有利于恢复肠道内环境稳定,疗效确切,且不良反应少,值得临床推广应用。
Objective To observe the clinical efficacy and adverse reactions of Jinshuangqi combined with Smecta in the treatment of infantile diarrhea. Methods 88 children with acute diarrhea were randomly divided into observation group (44 cases) and control group (44 cases). Both groups were given diet, oral or intravenous rehydration solution of ORS, correct water and electrolyte disturbance, correct the basis of acidosis and eating guide Treatment, the observation group on this basis with gold bifidobacteria, Smectite oral, treatment 3 d. The control group plus lactase Health, vitamin B complex oral, both groups were given to the disease under the conditions of cooling, antiemetic and other symptomatic treatment. Results The observation group was markedly effective in 37 cases (84.1%), effective in 6 cases and ineffective in 1 case, with a total effective rate of 97.7%. In the control group, 21 cases were markedly effective (47.7%), effective in 14 cases and ineffective in 9 cases. The total effective rate was 79.5% , The difference between the two groups was statistically significant (χ2 = 11.44, P <0.05). No significant adverse reactions occurred in both groups during treatment. Conclusion Jinshuangqi combined with Smecta treatment of children with diarrhea synergistic effect is conducive to the discharge of pathogenic microorganisms, is conducive to the restoration of stable intestinal environment, the exact effect, and fewer adverse reactions, it is worth promoting the clinical application.