冠状动脉痉挛(以下简称冠脉痉挛)在劳累型、变异型、ST段压低的稳定型、不稳定型心绞痛及急性心肌梗塞等广泛缺血性心脏病发病机理上起重要作用、其诊断常用过换气、冷加压试验、运动或应用麦角新硷、乙酰胆硷、乙酰甲胆硷、毛果芸香硷、肾上腺素、多巴胺、组织胺等药物的诱发试验,又可用亚硝酸盐类或钙离子拮抗剂终止和预防发作。本文介绍血小板和血清素与冠脉痉挛成因的关系。一、血管痉挛的发生机理目前对冠脉痉挛有植物神经调节异常说;血小板、前列腺素(PG)原因说;局部血管因素等学说。作者认为,冠脉痉挛与血管局部收缩反应亢进和舒张反应低下有关。动物试验及临床观察多认为冠脉痉挛 Coronary artery spasm (hereinafter referred to as coronary spasm) plays an important role in the pathogenesis of extensive ischemic heart disease such as exertion type, variant type, stable ST-segment depression, unstable angina pectoris and acute myocardial infarction. The diagnosis is commonly used Ventilation, cold compression test, exercise or application of ergometrine, acetylcholine, methacholine, pilocarpine, epinephrine, dopamine, histamine and other drugs induced test, but also nitrite or calcium Ion antagonists terminate and prevent seizures. This article describes the relationship between platelets and serotonin and causes of coronary spasm. First, the pathogenesis of vasospasm Present coronary artery spasm with abnormal regulation of autonomic said; platelets, prostaglandin (PG) reason; local vascular factors such as doctrine. The authors believe that coronary spasm and vascular local contractile response hyperactivity and diastolic response is low. More animal experiments and clinical observations that coronary artery spasm