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目的：研究卵巢上皮性交界性肿瘤的发生和发展，以及与卵巢上皮良恶性肿瘤之间的关系。方法：应用地高辛标记ｃ－ｍｙｃ和Ｐ￣（５３）基因探针对２０例良性、２４例交界性、２３例恶性卵巢上皮肿瘤进行原位杂交。结果：ｃ－ｍｙｃ和Ｐ￣（５３）在三种肿瘤组织中表达率分别为１０％，６６．７％，７８．２％和５％，５８．３％，７３．９％，在交界性肿瘤中的表达率介于良恶性肿瘤之间，而且阳性表达率和表达强度与肿瘤组织类型无关，与临床期别和病理分级有关，二者均定位于细胞核内。结论：结果表明卵巢上皮交界性肿瘤的发生及发展可能与ｃ－ｍｙｃ和Ｐ￣（５３）过量表达有关，并可将卵巢上皮交界性肿瘤视为癌前病变。
Objective: To study the occurrence and development of ovarian epithelial borderline tumors and their relationship with benign and malignant ovarian epithelial tumors. METHODS: In situ hybridization was performed on 20 benign, 24 borderline, and 23 malignant ovarian epithelial tumors using digoxigenin-labeled c-myc and P53 gene probes. Results: The expression rates of c-myc and P ̄ (53) in three tumor tissues were 10%, 66.7%, 78.2% and 5%, 58.3%, 73.9%, respectively. The expression rate among tumors was between benign and malignant tumors, and the positive expression rate and expression intensity were not related to the tumor tissue type. They were related to clinical stages and pathological grades. Both were located in the nucleus. Conclusions: The results suggest that the occurrence and development of borderline ovarian epithelial tumors may be related to the overexpression of c-myc and P53, and borderline ovarian epithelial tumors may be considered as precancerous lesions.