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目的:探索鉴别诊断胸腹水性质的有价值的实验室联合检测指标体系。方法:采用放射免疫分析,对251人份胸腹水中的甲胎蛋白(AFP)、癌胚抗原(CEA)、铁蛋白(Fer)、层粘连蛋白(LN)、绒毛膜促性腺激素(HCG)进行了综合性检测。结果:5项指标在良恶性胸腹水中均存在显著性差异(P＜0.01),此5项指标在恶性胸腹水中诊断阳性率依次为35.0%、65.8%、80.8%、75.8%和45.0%,联合测定后阳性率提高到95.8%。结论:AFP、CEA、Fer、LN、HCG联合测定,对于胸腹水性质的鉴别具有重要价值。
Objective: To explore a valuable laboratory joint detection index system for differential diagnosis of pleural effusion and ascites fluid. METHODS: A radioimmunoassay was performed on 251 human alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), ferritin (Fer), laminin (LN), and chorionic gonadotropin (HCG) Comprehensive tests were conducted. Results: There were significant differences in 5 indicators in benign and malignant chest and abdominal water (P<0.01). The positive rate of these 5 indicators in malignant hydrothorax and ascites was 35.0%, 65.8%, 80.8%, 75.8% and 45.0% respectively. The combined positive rate increased to 95.8%. Conclusion: The combined determination of AFP, CEA, Fer, LN and HCG has important value for the identification of pleural and ascitic fluid properties.