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本文对8例过敏性紫癜同时进行了光镜和电镜观察。光镜下见真皮浅层及乳头层毛细血管和小血管炎症性改变,血管周围有炎症细胞浸润及红细胞外渗,陈旧性皮疹可见含铁血黄素沉着。电镜下见炎症性血管的内皮细胞增生、肥大,管腔扩张或狭窄,并有微血栓及坏死性改变,较为突出的形态特点是血管壁由高电子密度带和低电子密度带相间排列,而使血管呈葱皮样结构。红细胞外渗和游走非常明显。根据形态观察,红细胞外渗似不能简单地认为是血管壁通透性增高的结果,是否存在着某种“作用因子”,值得进一步研究。由于红细胞没有细胞器,一旦渗透到血管外成为“异物”时,则不能自身清除,必须被巨噬细胞吞噬、消化;光镜下的所谓“含铁血黄素”实际上是指电镜下巨噬细胞中溶酶体的作用底物。
In this paper, 8 cases of anaphylactoid purpura were observed by light microscopy and electron microscopy. Light microscope, see the dermis and papillary capillaries and small blood vessels inflammatory changes around the blood vessels with inflammatory cell infiltration and erythrocyte extravasation, old rashes visible hemosiderin. Electron microscope, see inflammatory vascular endothelial cell proliferation, hypertrophy, lumen expansion or stenosis, and microthrombus and necrosis changes, the more prominent morphological characteristics of the vascular wall by the high electron density and low electron density with white and white, and The blood vessels were onion-like structure. Extravasation and migration of red blood cells is very obvious. According to morphological observation, erythrocyte extravasation can not be simply considered as the result of increased vascular wall permeability. Whether there is some “action factor” deserves further study. Since erythrocytes have no organelles, once they penetrate into the blood vessel and become “foreign bodies”, they can not clear themselves and must be phagocytosed and digested by macrophages. The so-called “hemosiderin” under the light microscope actually refers to electron microscopy of macrophages The role of lysosomes in the substrate.